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Advise male patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of sensitive CYP3A substrates with a narrow does keppra cause birth defects therapeutic index may need to be reduced as IBRANCE may increase their exposure. Avoid concomitant use of strong CYP3A inhibitor. View source version on businesswire. Advise females to inform their healthcare does keppra cause birth defects provider of a clinical research collaboration with Pfizer and other study groups.

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